Are autism and ADHD associated with antidepressants or maternal depression? The debate continues…

 

Amy Green summarises a retrospective observational study that finds prenatal antidepressant exposure is associated with risk for ADHD, but not autistic spectrum disorders. She considers this complex topic and works out what it all means for pregnant women with depression.

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CBT in primary care is cost-effective for treatment-resistant depression

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Elf economist Chris Sampson reports on the economic evaluation of the CoBalT RCT, which finds that CBT is cost-effective for treatment resistant depression in primary care.

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Exercise for the prevention and treatment of antenatal depression

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Meg Fluharty summarises a recent systematic review looking at exercise for antenatal depression. The review finds preliminary evidence to suggest that exercise may be effective in reducing depression during pregnancy, but the quality of included trials is low to moderate.

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Ketamine for depression: new review highlights the need for an RCT

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Helge Hasselmann reviews a new systematic review of ketamine for depression, which highlights the need for an RCT to provide reliable data on the safety, tolerability and best route of administration.

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Placebo for depression: are some sugar pills better than others?

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Joe Judge revels in a new network meta-analysis looking at placebo for depression published in BMC Medicine, which has been supplemented by a series of commentaries and blogs. Thought-provoking stuff!

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Interpersonal therapy and imipramine may be effective at reducing suicidal ideation in depression, but more research needed

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Susie Johnson considers how effective conventional depression treatments are at reducing suicidal ideation in depression. The new study she summarises concludes that interpersonal therapy and antidepressants can also reduce suicidal ideation.

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Face-to-face psychotherapy for chronic pain in children and adolescents: Cochrane review calls for better primary research

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Lisa Burscheidt summarises a recent Cochrane review of psychotherapy for chronic pain in children and adolescents, which concludes that psychological therapies should be considered as a treatment, but better primary studies are needed to help steer pain management decisions.

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Mental disorders after critical illness: depression, PTSD and functional disability in survivors of intensive care

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The BRAIN-ICU prospective cohort study published in the Lancet Respiratory Medicine looks at mental health outcomes and functional disabilities in a general ICU population. It explores the hypothesis that depressive symptoms after discharge are more often somatic (i.e. bodily complaints) than cognitive-affective (i.e. thought-related and mood-related complaints).

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Combining psychotherapy and antidepressants is best for common mental illnesses

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Patrick Kennedy-Williams summarises a recent meta-analysis, which finds that combined treatment with psychotherapy and antidepressants is more effective than treatment with antidepressants alone.

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Interpersonal counselling for depression: RCT shows some promise

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Mark Smith summarises an RCT which compares SSRI antidepressants with interpersonal counselling for depression. The trial explores moderators of remission with interpersonal counselling or drug treatment in primary care patients with mild-moderate depression.

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