Peer-led self-management for mental health: impressive programme, not so sure about the research

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Lucy Simons and Chris Sampson appraise a recent evaluation of peer-led self-management training for people with severe mental illness.

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The more psychotic you are, the more benefit there is in taking antipsychotics

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John Baker reviews a recent participant-level meta-analysis of six placebo-controlled studies, which looks at the initial severity of schizophrenia and the efficacy of antipsychotics including Olanzapine, Risperidone and Amisulpride.

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Another negative trial of cognitive bias modification: a case for Occam’s razor

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Ioana Cristea reviews a recent RCT that found no effects of positive imagery-based cognitive bias modification, delivered as a web-based treatment for people with depression.

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Personality disorder: time for more attention and debate

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Andrew Shepherd summarises a recent series of papers in The Lancet which look at the latest research on personality disorders. This includes evidence on classification, prevalence, diagnosis, treatment and the experience of personality disorder across the life course.

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Mindfulness-based cognitive therapy to prevent depression

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André Tomlin presents the results of the PREVENT RCT published today in The Lancet, which investigates the effectiveness and cost-effectiveness of mindfulness-based cognitive therapy compared with maintenance antidepressant treatment in the prevention of depressive relapse or recurrence.

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Dementia risk factors in people with mild cognitive impairment

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Akshay Nair summarises a recent systematic review and meta-analysis of modifiable predictors of dementia in mild cognitive impairment. The meta-analysis finds that diabetes and the presence of any neuropsychiatric symptoms significantly predicted the conversion of mild cognitive impairment to dementia.

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Screening for bipolar spectrum disorders (MDQ, BSDS and HCL-32)

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Elena Marcus appraises a recent meta-analysis of screening for bipolar spectrum disorders, which concludes that the MDQ and HCL-32 tools are supported by more evidence than the BSDS tool.

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Varenicline and the risk of neuropsychiatric adverse events and death

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Natasha Clarke publishes her debut Mental Elf blog about a new systematic review and meta-analysis investigating the risk of neuropsychiatric adverse events associated with the smoking cessation drug varenicline.

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A multitude of systematic reviews on dementia diagnosis

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Clarissa Giebel highlights 5 new Cochrane reviews on dementia diagnosis, focusing on the Mini-Cog, IQCODE and MMSE diagnostic tests.

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