Antidepressants for depression in pregnancy: new systematic review says the jury’s still out

Nikki Newhouse summarises a recent US health technology assessment of antidepressants for depression in pregnancy and the postpartum period, which concludes that the evidence remains inconclusive about the benefits and harms of antidepressants for depression in pregnancy.

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Tricyclic antidepressants for ADHD in children and adolescents: Cochrane review finds no evidence to support prescribing

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Helge Hasselman summarises a Cochrane review of tricyclic antidepressants for attention deficit hyperactivity disorder (ADHD) in children and adolescents, which finds low quality evidence and no justification for prescribing these drugs in this group of patients.

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Are autism and ADHD associated with antidepressants or maternal depression? The debate continues…

 

Amy Green summarises a retrospective observational study that finds prenatal antidepressant exposure is associated with risk for ADHD, but not autistic spectrum disorders. She considers this complex topic and works out what it all means for pregnant women with depression.

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Prenatal SSRI exposure and autism risk: a dilemma for mums-to-be with depression

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Amy Green summarises a population-based study of young children which looks at prenatal exposure to SSRI antidepressants and the social responsiveness symptoms of autism.

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Placebo for depression: are some sugar pills better than others?

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Joe Judge revels in a new network meta-analysis looking at placebo for depression published in BMC Medicine, which has been supplemented by a series of commentaries and blogs. Thought-provoking stuff!

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Interpersonal therapy and imipramine may be effective at reducing suicidal ideation in depression, but more research needed

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Susie Johnson considers how effective conventional depression treatments are at reducing suicidal ideation in depression. The new study she summarises concludes that interpersonal therapy and antidepressants can also reduce suicidal ideation.

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Mental disorders after critical illness: depression, PTSD and functional disability in survivors of intensive care

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The BRAIN-ICU prospective cohort study published in the Lancet Respiratory Medicine looks at mental health outcomes and functional disabilities in a general ICU population. It explores the hypothesis that depressive symptoms after discharge are more often somatic (i.e. bodily complaints) than cognitive-affective (i.e. thought-related and mood-related complaints).

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Combining psychotherapy and antidepressants is best for common mental illnesses

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Patrick Kennedy-Williams summarises a recent meta-analysis, which finds that combined treatment with psychotherapy and antidepressants is more effective than treatment with antidepressants alone.

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Antidepressants, safety warnings and suicide risk in young people

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Andrew Shepherd reviews the recent controversial BMJ study that suggests the FDA black box warning about antidepressant use in young people, may have inadvertently caused an increase in suicidal behaviour. He finds it’s not quite that clear cut.

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The adverse effects of psychiatric drugs and emergency department visits

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A new study finds that psychiatric medications are implicated in many adverse drug events treated in US emergency departments. Nearly 1 in 10 of all adverse drug event visits to emergency departments are due to psychiatric drugs, including antidepressants, antipsychotics, lithium salts, sedatives, anxiolytics and stimulants.

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