Bipolar disorder features as one of the top ten disabling disorders for working age adults. There are numerous risks including suicide, increased mortality and reduced social functioning associated with the disorder. Key to enabling recovery is preventing acute episodes from occurring, with each episode increasing the risk of future ones. [read the full story...]
Dementia is one of the most common and serious disorders in later life. It places a considerable burden on the health care system, individuals and especially unpaid carers. Depression is common among people with dementia and causes additional distress to affected individuals and their social circle. Research into the treatment [read the full story...]
SSRIs are usually considered first-line treatment against major depression and approximately 50% of patients achieve remission with the drug they try first (Steffens, Krishnan, & Helms, 1997). However, every eighth case proves to be treatment-resistant and does not respond to standard antidepressant treatment at all. As a last resort, second-generation [read the full story...]
Depression is a serious mental health threat proclaimed to be the greatest disease burden in the industrialised world by 2020 (Simon, 2003). In the pharmaceutical combat against depression, selective serotonin reuptake inhibitors (SSRIs) are the current treatment of choice. Indeed, SSRIs are the most prescribed antidepressant medicine (Helms & Eric, 2006). As [read the full story...]
Talking therapies for mental disorders are an ever-expanding field, with variations in treatments appearing all the time. It can be hard to know which treatment path to recommend to a patient, or which one you might choose for yourself. Major depressive disorder (MDD) is characterised by episodes of low mood, [read the full story...]
Studies have shown that the prevalence of depression in pregnant women is 7-19%. Being depressed during pregnancy can result in preterm delivery, which can in turn lead to illness and even death of the newborn child. Researchers have struggled to single out the causes of these risks. Is it the [read the full story...]
The CoBalT trial was published last week in the Lancet. This important randomised controlled trial (RCT) examined the effectiveness of cognitive behavioural therapy (CBT) as an add-on treatment to usual care for people with treatment resistant depression. Previous studies have shown that only around one third of people with depression [read the full story...]
Much of the research about depression in children and adolescents focuses on how to treat the illness during the acute phase. This review from the Cochrane Depression, Anxiety and Neurosis Review Group is more concerned with the ways in which interventions can be used to prevent relapse or recurrence of depressive disorders. The [read the full story...]
Research has shown that antidepressant use can lead to a non-significant increase in the risk of suicidal thoughts and behaviour in people aged under 25 (Stone et al, BMJ 2009). This subject rightly received a large amount of media coverage a few years ago and it remains an area where [read the full story...]
There are many different antidepressants to choose from when treating acute depression, so it’s always helpful to see a systematic review that looks at the efficacy, acceptability and tolerability of the different drugs. This new Cochrane review compares duloxetine hydrochloride (one of the newer drugs) with other antidepressants and finds [read the full story...]
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