Anti-inflammatory treatments for youth depression: promising but not yet implementable

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Céline Wessa reports on a recent systematic review of pharmacological anti-inflammatory treatment in children and adolescents with depressive symptoms, which has some promising results.

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Brain-body health please: new research supports integrated physical and mental health care

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Athina Aruldass finds that management of serious neuropsychiatric disorders should acknowledge the importance of poor physical health and target restoration of both brain and body function.

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Can proteomics improve our prediction of depression remission?

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Jonas Hagenberg discusses new insights into the possible use of proteomics (the large-scale study of proteins) for improving our prediction of depression remission.

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Predicting treatment-resistant psychosis using routine clinical measures

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Lorna Staines summarises a recent study on predicting treatment-resistant psychosis, which suggests that future risk prediction efforts should seek to consider routinely collected data.

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Gut microbiome disruptions in depression: shifting the focus to metabolic signatures in blood

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Gerard Clarke explores a recent study which looks into the interplay of metabolome and gut microbiome in individuals with major depressive disorder.

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Cellular immune phenotypes of depression: a gateway to precision medicine 

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In her debut blog, Fabiana Corsi-Zuelli summarises a recent systematic review and meta-analysis investigating the role of peripheral immune cells in depression, with a focus on implications for future immunotherapy trials.

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Can brain scans tell us how successful CBT for anxiety will be? Meta-analysis of task-based fMRI studies shows promise

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Millie Lowther, Isabel Luetkenherm, Carlos Mena and Alexandra Pike summarise a recent fMRI meta-analysis, which finds that activation in brain circuits related to salience, interoception and emotional processing were found to predict a positive response to CBT in anxiety disorders.

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Pulpitis – How effective are diagnostic tests?

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This review of clinical tests for the diagnosis of the condition of the dental pulp included 28 studies from 29 publications. The quality of the included studies was low providing limited scientific evidence regarding the accuracy and reproducibility of diagnostic tests.

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Cerebrospinal fluid biomarkers for depression

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In her debut blog, Éimear Foley reviews a recent meta-analysis that identifies possible differences between people experiencing depression and healthy controls.

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Deep brain stimulation for severe depression: could ‘brain pacemakers’ be the answer for some?

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Alexandra Pike, Alexis An Yee Low and Jonathan Roiser critically appraise a recent n-of-1 study on ‘brain pacemakers for depression’, which received extensive press coverage earlier this month. The case study looks at deep brain stimulation (closed-loop neuromodulation) in an individual with treatment-resistant depression.

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