Childhood adversity linked to psychotropic drug use in later life

shutterstock_121428757

Andrew Jones summarises a large Finnish population-based cohort study, which finds that childhood adversities strongly predict the use of psychotropic drugs (such as antidepressants and antipsychotics) in adulthood.

[read the full story...]

Helping people with depression return to work

shutterstock_213396637

Meg Fluharty reports on a new Cochrane review of interventions to improve return to work in depressed people. The review finds moderate quality evidence for a range of work-directed and clinical interventions that can help people with depression return to work.

[read the full story...]

Folic acid for depression: results of the FolATED study

shutterstock_32144176

Susie Johnson reports on the FolATED RCT and economic evaluation of folic acid for depression. The study finds no evidence that folic acid is clinically effective or cost-effective in augmenting antidepressants and speculates instead that methylfolate may be a better candidate for future research.

[read the full story...]

Medication for the maintenance treatment of bipolar disorder

shutterstock_162124046

Elena Marcus summarises a recent network meta-analysis published in The Lancet of the comparative efficacy and tolerability of medication for the maintenance treatment of bipolar disorder.

[read the full story...]

Collaborative care for depression: psychological interventions, alone or in combination with medication, offer additional benefits

A recent meta-analysis sought to identify factors associated with improvement in patient outcomes and in the process of care

Ioana Cristea reviews a recent systematic review and meta-analysis of collaborative care for depression, looking to identify factors predicting improvements. The study finds that collaborative care successfully improves both patient outcomes and the process of care for depression.

[read the full story...]

Depression and cancer: Lancet papers on prevalence and integrated collaborative care

double_dip__cvent

Kirsten Lawson highlights a trio of Lancet papers on the prevalence of depression in cancer patients and the efficacy of a new treatment programme called ‘Depression Care for People with Cancer’.

[read the full story...]

Collaborative care for adolescent depression: new RCT shows promise

shutterstock_125165846

Jennifer Laidlaw writes her debut blog on a recent RCT in JAMA about collaborative care for adolescent depression in primary care. The trial concludes that collaborative care is both feasible and effective in improving outcomes, but Jennifer highlights a number of limitations and questions for future research.

[read the full story...]

Cognitive therapy plus antidepressants for depression

shutterstock_173869289

Patrick Kennedy-Williams highlights a new large-scale RCT of combined cognitive therapy plus antidepressants for major depressive disorder. The trial finds that this combination is effective, but only in patients with severe non-chronic depression.

[read the full story...]

Antidepressants for depression in pregnancy: new systematic review says the jury’s still out

Nikki Newhouse summarises a recent US health technology assessment of antidepressants for depression in pregnancy and the postpartum period, which concludes that the evidence remains inconclusive about the benefits and harms of antidepressants for depression in pregnancy.

[read the full story...]

Tricyclic antidepressants for ADHD in children and adolescents: Cochrane review finds no evidence to support prescribing

shutterstock_147565085

Helge Hasselman summarises a Cochrane review of tricyclic antidepressants for attention deficit hyperactivity disorder (ADHD) in children and adolescents, which finds low quality evidence and no justification for prescribing these drugs in this group of patients.

[read the full story...]