Lisdexamfetamine for binge-eating disorder

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David Steele summarises a recent randomised controlled trial, which finds that (in the short-term) Lisdexamfetamine successfully decreased binge-eating behaviour in patients with binge-eating disorder. But can we trust this evidence?

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Engaging inpatients with mental health rehabilitation activities

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Elly O’Brien reports on a recent RCT of a staff training intervention for inpatients in mental health rehabilitation, which is designed to increase patients’ engagement in activities.

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Helping people with depression return to work

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Meg Fluharty reports on a new Cochrane review of interventions to improve return to work in depressed people. The review finds moderate quality evidence for a range of work-directed and clinical interventions that can help people with depression return to work.

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Brief interventions for substance misuse in primary care

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Claire Mokrysz reports on two RCTs in JAMA that find no superiority over control for brief interventions for substance misuse in primary care. A finding that casts some doubt on interventions such as motivational interviewing for unhealthy drug use in primary care patients.

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Folic acid for depression: results of the FolATED study

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Susie Johnson reports on the FolATED RCT and economic evaluation of folic acid for depression. The study finds no evidence that folic acid is clinically effective or cost-effective in augmenting antidepressants and speculates instead that methylfolate may be a better candidate for future research.

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Folic acid for depression: RCT finds no effect on reducing incidence of depression or bipolar

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Elly O’Brien summarises a recent RCT of folic acid for depression, which explores whether mood disorders can be prevented in young people at familial risk. The trial finds no evidence that folic acid supplementation reduces the incidence of mood disorders compared to those taking placebo.

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Sustained smoking cessation intervention for hospitalised smokers

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Sally Adams summarises a new randomised controlled trial in JAMA, which tests a sustained care intervention and post-discharge smoking cessation for hospitalised smokers.

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Improving mental health literacy in the classroom: new HeadStrong RCT

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Lisa Burscheidt reports on an RCT of the Headspace mental health literacy intervention and the impact it has on the mental health literacy, stigma, help-seeking and mental health of a group of young people in Australia.

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Depression and cancer: Lancet papers on prevalence and integrated collaborative care

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Kirsten Lawson highlights a trio of Lancet papers on the prevalence of depression in cancer patients and the efficacy of a new treatment programme called ‘Depression Care for People with Cancer’.

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Collaborative care for adolescent depression: new RCT shows promise

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Jennifer Laidlaw writes her debut blog on a recent RCT in JAMA about collaborative care for adolescent depression in primary care. The trial concludes that collaborative care is both feasible and effective in improving outcomes, but Jennifer highlights a number of limitations and questions for future research.

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