Long duration of untreated psychosis is associated with a range of poor outcomes

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Joe Judge appraises a recent systematic review and meta-analysis looking at the duration of untreated psychosis as a predictor of long-term outcomes in schizophrenia.

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Antidepressants for depression in pregnancy: new systematic review says the jury’s still out

Nikki Newhouse summarises a recent US health technology assessment of antidepressants for depression in pregnancy and the postpartum period, which concludes that the evidence remains inconclusive about the benefits and harms of antidepressants for depression in pregnancy.

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Efficacy of high vs. low-potency first-generation antipsychotics for schizophrenia

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Laurence Palfreyman summarises 3 recent Cochrane reviews, which investigate high-potency versus low-potency first-generation antipsychotic drugs for schizophrenia. The reviews find little difference in efficacy between the high-potency antipsychotics Trifluoperazine, Haloperidol, Fluphenazine, and low-potency typical antipsychotics.

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Schizophrenia and osteoporosis: sticks and stones may break my bones…

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Chris Pell summarises a recent meta-analysis of prevalence estimates and moderators of low bone mass in people with schizophrenia. The study finds a significantly increased risk of osteoporosis in people with schizophrenia.

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Exercise for the prevention and treatment of antenatal depression

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Meg Fluharty summarises a recent systematic review looking at exercise for antenatal depression. The review finds preliminary evidence to suggest that exercise may be effective in reducing depression during pregnancy, but the quality of included trials is low to moderate.

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Cannabis use in young people linked with lower high school completion and degree attainment

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André Tomlin and Douglas Badenoch voice a note of caution about the Lancet Psychiatry meta-analysis of cannabis use in young people. The study links cannabis use in children with low educational attainment, cannabis dependence, illicit drug use and suicide attempts in later life.

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Ketamine for depression: new review highlights the need for an RCT

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Helge Hasselmann reviews a new systematic review of ketamine for depression, which highlights the need for an RCT to provide reliable data on the safety, tolerability and best route of administration.

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Placebo for depression: are some sugar pills better than others?

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Joe Judge revels in a new network meta-analysis looking at placebo for depression published in BMC Medicine, which has been supplemented by a series of commentaries and blogs. Thought-provoking stuff!

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Face-to-face psychotherapy for chronic pain in children and adolescents: Cochrane review calls for better primary research

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Lisa Burscheidt summarises a recent Cochrane review of psychotherapy for chronic pain in children and adolescents, which concludes that psychological therapies should be considered as a treatment, but better primary studies are needed to help steer pain management decisions.

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