Lifestyle changes for cognition and dementia: better than a new drug?

shutterstock_2378100

Should all molecular research institutes looking at neurodegenerative diseases be replaced by parks, playgrounds and cycle paths? Mark Horowitz highlights a recent systematic review of modifiable risk factors associated with cognition and dementia, which suggests that from a public health perspective, there may be some sense in this idea.

[read the full story...]

Risk factors for dementia: separating the facts from the myths

shutterstock_223825078

We are grateful to Josephine Neale who has read the 104 page World Alzheimer Report 2014 and summarised it for us in this very readable blog. The report is a comprehensive analysis of the risk factors for dementia, which focuses on a range of protective and modifiable factors.

[read the full story...]

Medication in advanced dementia: how can we judge what is appropriate?

shutterstock_219711667

Caroline Struthers appraises a recent US cross-sectional study of the use of medications of “questionable benefit” in nursing home residents with advanced dementia. She concludes that all medications are of questionable value if they have side effects which might have a negative impact on quality of life or are likely to cause harm.

[read the full story...]

Cognitive and exercise interventions for older adults with and without cognitive impairment

Image: Diabetes Care (CC BY-NC 2.0)

Jake Crawshaw reports on a recent systematic review of cognitive and exercise interventions for older people with and without cognitive impairment.

[read the full story...]

Meta-review presents the risks of all-cause and suicide mortality in mental disorders

shutterstock_177940451

This recent and well-conducted meta-review concludes that the impact on mortality and suicide of mental disorders is substantial, and probably poorly appreciated as a public health problem. Raphael Underwood’s blog summarises the data for all-cause and suicide mortality in mental disorders.

[read the full story...]

Alternatives to medication for agitation in dementia

shutterstock_183376727

Andrés Fonseca summarises the findings of a recent systematic review of the clinical effectiveness and cost-effectiveness of sensory, psychological and behavioural interventions for managing agitation in dementia.

[read the full story...]

Statins have no beneficial effect on cognition in dementia, but can cause serious side-effects

shutterstock_158586293

This updated Cochrane review on statins for the treatment of dementia contains worrying adverse effects data, but Caroline Struthers has to do a significant amount of digging to root it all out.

[read the full story...]

What should we prescribe for neuropsychiatric symptoms in Alzheimer’s disease?

shutterstock_70709260

Psychiatrist Andrés Fonseca considers how his clinical practice should change, after reading a systematic review and meta-analysis of drug treatment for neuropsychiatric symptoms in Alzheimer’s disease

[read the full story...]