Medication for the maintenance treatment of bipolar disorder

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Elena Marcus summarises a recent network meta-analysis published in The Lancet of the comparative efficacy and tolerability of medication for the maintenance treatment of bipolar disorder.

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Folic acid for depression: RCT finds no effect on reducing incidence of depression or bipolar

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Elly O’Brien summarises a recent RCT of folic acid for depression, which explores whether mood disorders can be prevented in young people at familial risk. The trial finds no evidence that folic acid supplementation reduces the incidence of mood disorders compared to those taking placebo.

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Stigma in bipolar disorder and borderline personality disorder: time for a cultural shift.

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Andrew Shepherd summarises a critical realist analysis that looks at experiences of stigma in people with bipolar disorder or borderline personality disorder. He concludes that a profound social change in public and professional attitudes is necessary before mental health stigma can be effectively eradicated.

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Cannabis and mania: what’s the link?

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Kathryn Walsh summarises a systematic review which finds that cannabis use may exacerbate symptoms of mania in those with a diagnosis of bipolar disorder, and trigger symptoms of mania in the general population.

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Bipolar disorder, suicide and criminality

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Elena Marcus summarises a double case-cohort study, which investigates the risk of suicide and criminal behaviours in people with bipolar disorder and their siblings, compared with the general population.

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Are treatments for bipolar disorder cost-effective?

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Chris Sampson reports on a recent systematic review and critical appraisal of economic evaluations in bipolar disorder. He finds that there’s a pressing need for new studies, especially discrete event simulations.

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Bipolar disorder and leadership: evidence from a total population study

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Elena Marcus writes her debut blog on a total population study that finds some interesting associations between bipolar disorder and leadership potential, executive roles and political professions.

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Ketamine for depression: new review highlights the need for an RCT

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Helge Hasselmann reviews a new systematic review of ketamine for depression, which highlights the need for an RCT to provide reliable data on the safety, tolerability and best route of administration.

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Exercise for severe mental illness: new review finds few benefits

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This new systematic review concludes that exercise programmes can lead to an improvement in exercise activity, but have no significant effect on mental health symptoms or body weight in people with severe mental illness.

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Meta-review presents the risks of all-cause and suicide mortality in mental disorders

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This recent and well-conducted meta-review concludes that the impact on mortality and suicide of mental disorders is substantial, and probably poorly appreciated as a public health problem. Raphael Underwood’s blog summarises the data for all-cause and suicide mortality in mental disorders.

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