Long duration of untreated psychosis is associated with a range of poor outcomes

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Joe Judge appraises a recent systematic review and meta-analysis looking at the duration of untreated psychosis as a predictor of long-term outcomes in schizophrenia.

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Smoking cessation in the emergency setting

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Olivia Maynard summarises a systematic review of smoking cessation interventions in the emergency setting, which highlights the poor quality and heterogenous nature of the published trials in this field.

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Antidepressants for depression in pregnancy: new systematic review says the jury’s still out

Nikki Newhouse summarises a recent US health technology assessment of antidepressants for depression in pregnancy and the postpartum period, which concludes that the evidence remains inconclusive about the benefits and harms of antidepressants for depression in pregnancy.

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Tricyclic antidepressants for ADHD in children and adolescents: Cochrane review finds no evidence to support prescribing

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Helge Hasselman summarises a Cochrane review of tricyclic antidepressants for attention deficit hyperactivity disorder (ADHD) in children and adolescents, which finds low quality evidence and no justification for prescribing these drugs in this group of patients.

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Medication in advanced dementia: how can we judge what is appropriate?

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Caroline Struthers appraises a recent US cross-sectional study of the use of medications of “questionable benefit” in nursing home residents with advanced dementia. She concludes that all medications are of questionable value if they have side effects which might have a negative impact on quality of life or are likely to cause harm.

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Cyberbullying and mental health in young people

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Elly O’Brien summarises a recent US survey of adolescents, which investigates the relationship between cyberbullying, mental health and substance use problems, and the moderating role of family dinners.

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Reducing benzodiazepine prescribing in primary care

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Liz Hughes summarises two recent studies (1 systematic review and 1 RCT) that both investigate brief interventions for reducing the use of benzodiazepines in primary care.

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Efficacy of high vs. low-potency first-generation antipsychotics for schizophrenia

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Laurence Palfreyman summarises 3 recent Cochrane reviews, which investigate high-potency versus low-potency first-generation antipsychotic drugs for schizophrenia. The reviews find little difference in efficacy between the high-potency antipsychotics Trifluoperazine, Haloperidol, Fluphenazine, and low-potency typical antipsychotics.

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Second National Audit of Schizophrenia highlights lack of progress for service users and carers

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André Tomlin summarises the second National Audit of Schizophrenia, which highlights that many people with schizophrenia are still not getting the high quality psychological and medical treatment they deserve.

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Lost in anxiety: treatment-resistant anxiety in older people

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Andrés Fonseca appraises a new systematic review of interventions for treatment-resistant anxiety in older people, which finds a disconcerting lack of evidence to help him support the many older patients he sees who are affected by anxiety disorders.

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